Abstract #1478

Detection of Pulmonary Embolism with Hyperpolarized 3He MRI: A Comparison of PO2-Based and Susceptibility-Based Techniques

Michelle E. Law¹, Jiangsheng Yu¹, Stephen Kadlecek¹, Kiarash Emami¹, Masaru Ishii², John MacDuffie-Woodburn¹, Matthew Stetz¹, Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, USA; ²Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA

Hyperpolarized 3He MRI has been applied to diagnosis pulmonary emboli. In this work, we present a comparison of pO2-based and susceptibility-based hyperpolarized 3He MRI techniques for the detection of pulmonary emboli in a pig model. The experiment results show that the pO2-based technique is more sensitive than the susceptibility-based technique.