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Abstract #1493

Deletion of the Brain-Specific Link Protein BRAL-1 Facilitates Extracellular Diffusion in the Mouse Corpus Callosum

Ivan Vorisek1,2, Lydia Vargova2,3, Lesia Dmytrenko1, Yoko Bekku4, Toshitaka Oohashi4, Eva Sykova1,2

1Department of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic; 2Center for Cell Therapy and Tisue Repair, Charles University, 2nd Medical Faculty, Prague, Czech Republic; 3Department of Neuroscience, Charles University, 2nd Medical Faculty, Prague, Czech Republic; 4Department of Mollecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

Besides morphological techniques, the structure of the nervous tissue may be revealed by the diffusion of substances in the extracellular space (ECS). The efficacy of extrasynaptic transmission between neurons and between neurons and glia is based on the diffusion of neuroactive substances in the ECS and depends on the diffusion properties of the ECS. Our previous studies revealed that changes in the extracellular matrix substantially affect the diffusion properties of nervous tissue. In the present study we examined three parameters describing the diffusion of molecules and neuroactive substances in the cortex and corpus callosum of BRAL1 positive and negative mice.