Abstract #1507

Multi-Slice Absolute Cerebral Blood Volume Quantification on Animal Model Using a Hybrid Method of Vascular Space Occupancy and Susceptibility Effect of MION

Chien-Chung Chen¹, Young Ro Kim², Yi-Chun Wu¹, Chou-Ming Cheng³, Tzu-Chen Yeh³, Fu-Nien Wang¹

¹Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, Taiwan; ²Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; ³Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan

A hybrid method combing the advantage of Vascular Space Occupancy, Dynamic Susceptibility Contrast imaging, and susceptibility induced R2 increase by long half-life contrast agent MION are proposed to measuring absolute cerebral blood volume (CBV) with multiple slices on animal model. The correlation between these method are high and therefore a regression can be utilized to convert multi-slices relative CBV values to absolute quantifications, which could be beneficial to measuring whole brain perfusion on animal experiments.