Jacob Ellegood1, Ameet S. Sengar2, Michael W. Salter2, Sean E. Egan3, Jason P. Lerch1, R Mark Henkelman1
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada; 3Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
Diffusion Tensor Imaging (DTI) of fixed mouse brain is useful in examining development and genetic differences between wild type and knockout mouse models. Tractography using DTI, allows a qualitative visualization of changes in the morphology of white matter and has had limited use in mouse phenotyping. The purpose of this study was to assess anatomical changes non-invasively in the white matter of a genetically altered mouse model with associated white matter abnormalities.
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