Abstract #1562

Improved Separation of Tissue Oxygenation Extraction Fraction and Deoxygenated Blood Volume by Using the QBOLD Technique.

Jan Sedlacik¹, Jrgen R. Reichenbach², Claudia M. Hillenbrand¹

¹St. Jude Children's Research Hospital, Memphis, TN, USA; ²Friedrich Schiller Universitt, Jena, Germany

He and Yablonskiy introduced a quantitative BOLD method for tissue oxygenation extraction fraction (OEF) and deoxygenated blood volume (DBV) estimation. However, the calculation of OEF and DBV can be erroneous or deliver ambiguous results when both parameters are unknown and have to be estimated simultaneously. The purpose of this work was to develop a model strategy for more accurate OEF and DBV fitting based on the analysis of the imaginary part of the tissue model signal which is decoupled from the signal of the tissue matrix.