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Abstract #1617

Integrated Magnetic Field Variation Correction for Quantitative FMRI

John David Dickson1, Guy B. Williams2, Sally Georgia Harding2, Thomas Adrian Carpenter2, Richard E. Ansorge1

1Cavendish Laboratory, Cambridge University, Cambridge, Cambs, UK; 2Wolfson Brain Imaging Centre, Cambridge University, UK

It is possible to measure the venous Cerebral Blood Volume (vCBV) and Oxygen Extraction Fraction (OEF) by quantifying the BOLD signal. If this is to be used in a routine clinical setting then the scan times must be kept low. This study shows how the need for an external fieldmapping acquisition can be avoided using an integrated algorithm based on the phase data. These methods are shown to provide realistic measures of OEF and vCBV in a healthy volunteer.