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Abstract #1623

Theoretical Prediction of Parameter Stability in Quantitative BOLD MRI: Dependence on SNR and Sequence Parameters

Maja Cornelia Sohlin1, Lothar R. Schad2

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 2Computer Assisted Clinical Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Germany

A static dephasing model that analytically connects BOLD signal to hemodynamic parameters can be used to map the blood oxygenation level (Y) and venous cerebral blood volume (vCBV) in the brain. In this work, the accuracy of the method is tested by means of simulations and measurements. The result shows that accurate fitting can only be performed at high SNR (>500). A separate quantization of the vCBV would allow a stable method to quantify blood oxygenation even at low SNR (<200).