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Abstract #1653

Manipulation of BOLD Resting-State Functional Connectivity and Task Related BOLD FMRI Signal by Different Anesthetic Dosages

Anthony G. Hudetz1, Bharat B. Biswal2, Rupeng Li3, James S. Hyde3, Christopher Paul Pawela4

1Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; 2Department of Radiology, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 3Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA; 4Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA

The BOLD mechanism for task-related fMRI has been shown to be directly linked to underlying electrophysiological local field potentials. The mechanism for BOLD resting-state functional connectivity magnetic resonance imaging is still a subject of ongoing debate. In this study, the fMRI response to electrical stimulation frequency was used as an indirect measure of neuronal activity through anesthetic manipulation in a rat model. fcMRI acquisitions were also obtained prior to stimulation and compared to the fMRI results. Differences between the fMRI and fcMRI results under different anesthetic conditions are noted and discussed.