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Abstract #1752

Preservation of Cardiac Function in Transient Receptor Potential V4 Knockout Mice After Myocardial Infarction Measured by Magnetic Resonance Imaging

Gregory Turner1, Weike Bao, Beat Jucker, Kevin Thorneloe, Robert Willette

1GlaxoSmithKline, King of Prussia, PA, USA

The Transient Receptor Potential V4 (TRPV4), expressed in endothelium throughout the cardiovascular system, is a cation channel that contributes to intracellular Ca++ homeostasis and cell volume regulation . Pharmacologic activation of TRPV4 has been associated with circulatory collapse and failure of the endothelial barrier. In the present study, the effects of TRPV4 deletion (TRPV4-/-) on cardiac function was examined in a myocardial infarction (MI) model. MRI revealed preservation of cardiac function in the TRPV4-/- mouse 1 week post-MI. These results indicate that TRPV4 deletion produces a cardio-protective phenotype and suggests an important relationship between the endothelium and cardiac function.