Assessment of Left Ventricular Myocardial T1 Hyperintesity in Patients with Suspected Cardiac Amyloidosis Using MRI

Kirsi M. Taimen¹, MIchael C. Yang¹, Karin Dill¹, John Sheehan¹, James C. Carr¹

Amyloidosis is a systemic disease caused by extracellular deposition of insoluble protein. Cardiac involment is common and often fatal form of disease. Cardiovascular magnetic resonance exhibits late enhancement and shorter T1 in cardiac amyloidosis. We assessed T1 signal in cardiac amyloidosis using T1 weigheted gradient echo (GRE) technique and compared findings in age-matched control group. Results show that left ventricular myocardium is T1 hyperinterse on pre-contrast T1-GRE imaging in patients with suspected amyloidosis. They also have a shorter TI compared to controls following contrast administration.