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Abstract #1784

Detection of Myocardial Microvascular Disease in Latino Type-I Diabetes Mellitus Patients Using P-31 MRS

Hee-Won Kim1, Gerald M. Pohost1,2, Padmini Varadarajan2, Rohit Varma3, Milena Ocon1, Karam Souibri4, Rafit Drori5, Patrick Colletti1, Adina E. Zeidler4

1Radiology, University of Southern California, Los Angeles, CA, USA; 2Cardiology, Loma Linda University, Loma Linda, CA, USA; 3Ophthalmology, University of Southern California, USA; 4Medicine, University of Southern California, USA; 5Hillel Yaffe Medical Center, Hadera, Israel

The change of high energy phosphate in the heart during the stress was measured using stress cardiac P-31 MRS at 3T in order to identify impaired left ventricular function that is associated with reversible, exercise-induced metabolite alteration among Latino Type-1 diabetes mellitus (DM) patients. The significant drop of PCr/ATP during stress was found in 29% of overall patients and in 57% of the patients with retinopathy, while no significant drop in normal controls. Bioenergetic changes present among Type-1 DM patients may suggest systemic microvascular disorder, and the non-invasive P-31 cardiac MRS may facilitate the prediction of cardiomyopathy in such patients.