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Abstract #1785

High Resolution Cardiac 31P 2D MRS Using an Actively Decoupled Coil Setup for Metabolic Phenotyping in Mice

Mahon L. Maguire1, Hannah Barnes1, Andrew Webb2, Stefan Neubauer1, Jurgen E. Schneider1

1Department of Cardiovascular Medicine, Oxford University, Oxford, Oxfordshire, UK; 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

The mouse is the predominant species used in cardiac research. Both phosphocreatine and ATP levels are known to be perturbed in severe heart failure. Here we present the highest resolution mouse cardiac 31P chemical shift imaging data yet published. Acquired using a custom built actively decoupled coil arrangement with cardiac gating, and an acquisition weighted CSI pulse sequence, voxel sizes of 1.1x1.1x5.0 mm have been acquired within the context of a recovery experiment. This allows the possibility to directly interrogate high energy phosphate metabolism in a mouse model of heart failure within a longitudinal study of disease progression