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Abstract #1796

Comprehensive Evaluation of Diastolic Function with MRI

Richard Thompson1, June Cheng Baron1, Kelvin Chow1, Jessica Scott2, Ben Esch2, Mark Haykowsky3, Ian Paterson4

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada; 2Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada; 3Physical Therapy, University of Alberta, Edmonton, AB, Canada; 4Division of Cardiology, University of Alberta, Edmonton, AB, Canada

Diastolic dysfunction is a contributing factor in most cardiovascular diseases. Ventricular relaxation is impaired prior to changes in systolic function and a third to a half of all cases of heart failure have preserved systolic function (LVEF >50%). Despite this prevalence, the importance of diastolic dysfunction in the many diverse manifestations of heart failure is not well characterized. We illustrate the measurement of conventional and novel diastolic parameters using universally available clinical MRI pulse sequences in healthy controls and a population of heart failure patients, highlighting the predominance of diastolic dysfunction in a diverse range of heart failure etiologies.