Abstract #1837

Comparison of USPIO-Enhanced MRI and Magnetically Labelled Cell Tracking for Inflammation Detection in ApoE Mice

Olivia Monica Sigovan¹, Amine Bessaad¹, Hassan Alsaid¹, Genevieve De Souza¹, Claire Corot², Nicolas Provost³, Zouher Majd³, Christine Menager⁴, Norbert Nighoghossian¹, Serge Nataf⁵, Emmanuelle Canet-Soulas¹

¹CREATIS-LRMN Laboratory, University of Lyon, Lyon, France; ²Research, Guerbet, Paris, France; ³Technology Development, Genfit, Lille, France; ⁴Laboratoire Liquides Ioniques et Interfaces Charges, Pierre et Marie Curie University, Paris, France; ⁵U842, INSERM, Lyon, France

There is a clinical need for a noninvasive atherosclerosis assessment. Two contrast-enhanced MR strategies were compared for detecting inflammation in atherosclerosis. Alipoprotein-E (ApoE) modified mice were investigated at 4.7T in a 4 day follow up. One group received a retro-orbital injection of a rapid pharmacokinetics USPIO (Guerbet, France). For the second group, magnetically labeled macrophages were administered. The free particle injection strategy allows reliable inflammation detection and has the advantage of being directly applicable in clinics. Magnetically labeled cell tracking enables a direct view of a specific cellular type, providing valuable information on the lesion inflammatory status.