Malgorzata Marjanska1, Lisa Chow2, Gregor Adriany1, Elizabeth R. Seaquist2, Michael Garwood1
1Center for Magnetic Resonance Research and
Department of Radiology, University of Minnesota, Minneapolis, MN, USA; 2Division
of Endocrinology, Diabetes, and Metabolism, University of Minnesota,
Minneapolis, MN, USA
In vivo 1H spectroscopy in skeletal muscle has been more frequently performed in the lower leg than the thigh. It has been shown at 3 T that ankle orientation alters bulk susceptibility and residual dipolar couplings of protons in the calf skeletal muscle. With in vivo 1H MRS, changes in the residual dipolar couplings have been observed on creatine and TMA with ankle orientation. Additionally, changes in ankle orientation also affected the separation of intramyocellular and extramyocellular lipids. In this project, we investigate the influence of ankle orientation on 1H spectra from the thigh, specifically the vastus lateralis muscle.