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Abstract #2043

In Vivo Localized 1D and 2D MRS of Rat Kidney Using a Clinical 3T MRI/MRS Scanner

S. Sendhil Velan1, Kevin Engels2, Susan Lemieux1, Raymond R. Raylman1, Vazhaikkurichi M. Rajendran3

1Center for Advanced Imaging and Department of Radiology, West Virginia University, Morgantown, WV, USA; 2Department of Physiology, West Virginia University, Morgantown, WV, USA; 3Section of Digestive Diseases, Department of Medicine, West Virginia University, Morgantown, WV, USA

We have implemented advanced MRS techniques to investigate rat kidney. Our preliminary investigation demonstrates the presence of two sets of lipid signals. The intracellular signals may not come from renal cells; they may be from adipose cells or from accumulation of lipids through foam-cell formation. The non-invasive assessment of biochemistry in the kidney should be helpful in understanding physiological responses as well as disease induced adaptation in this complex organ.