Chris A. Flask1,2, David Johnson2, Vikas Gulani1, Rania Osman3,4, Nita Hoxha3,4, Katherine MacRae Dell3,4
1Radiology, Case Western Reserve University,
Cleveland, OH, USA; 2Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, USA; 3Pediatrics, Case Western Reserve University,
Cleveland, OH, USA; 4Rammelkamp Center for Education and Research,
MetroHealth Medical Center, Cleveland, OH, USA
Autosomal Recessive Polycystic Kidney Disease (ARPKD), overall kidney function diminishes only after significant disease progression. In addition, ARPKD is characterized by both macrocysts and microcysts which are not consistently delineated by conventional diagnostic imaging techniques. Our initial results in the PCK rat model of ARPKD demonstrate that quantitative MRI techniques such as Diffusion Weighted Imaging overcome this obstacle and allow non-invasive monitoring of ARPKD disease progression. We have also developed a quantitative analysis methodology to provide consistent characterization of ARPKD kidneys that can be easily translated to clinical applications.