Abstract #2052

Quantitative Analysis of Peristaltic and Segmental Motilities in the Rat GI Tract with Dynamic MRI and Spatio-Temporal Maps

Amit Ailiani¹, Thomas Neuberger², Gino Banco³, James Brasseur³, Nadine Smith¹, Andrew Webb⁴

¹Bioengineering, Penn State University, University Park, PA, USA; ²Huck Institute, Penn State University, USA; ³Mechanical Engineering, Penn State University; ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands

Non-invasive dynamic MRI in the jejunum region of an anesthetized rat has been used to produce spatiotemporal maps representing peristaltic and segmental motions. Frequency analysis of these motions give results which are in good agreement with previous work which has all been performed using highly invasive techniques involving external isolation of the gut. Dynamic MRI provides quantitative information on many physiological parameters such propagation velocity, wavelength, speed of collapse and the period of the motilities. Physiological parameters which are not dependent upon the exact position of the MRI slice were found to be statistically the same between animals (n=6).