Abstract #2053

MRI Assessment of the Effects of the Physical Form of a Meal on Gastric Emptying, Gallbladder Contraction, Small Bowel Water Content and Satiety

Luca Marciani¹, Nicholas Hall¹, Caroline L. Hoad², Susan E. Pritchard², Eleanor F. Cox², John J. Totman³, Robin C. Spiller¹, Penny A. Gowland²

¹Nottingham Digestive Diseases Centre Biomedical Research Unit, University of Nottingham, Nottingham, UK; ²Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, UK; ³Brain and Body Centre, University of Nottingham, Nottingham, UK

Manipulating the physical form of food may have an impact on gastrointestinal function and satiety. We hypothesised that feeding to healthy volunteers a solid/liquid meal blended to a soup: (a) gastric volumes would fall more slowly (b) satiety would be enhanced (c) the CCK duodenal response (as inferred from gallbladder contraction) would be enhanced and (d) the small bowel secretion would be greater. We were able to test these hypotheses by carrying out carried one satiety study in quiet controlled conditions and one mechanistic study using serial, functional gastrointestinal MRI.