Abstract #2056

Assessment of Tumor Microcirculation in Rectum Carcinoma with Regard to Different Pharmacokinetic Models, Intra- Tumor Heterogeneity and Therapeutic Effects After Neoadjuvant Radio-Chemotherapy

Andreas Markus Hoetker¹, Peter Mildenberger¹, Theo Junginger², Christoph Dueber³, Torsten Hansen⁴, Matthias Menig⁵, Andreas Pohlmann, Achim Heintz⁶, Katja Oberholzer³

¹Klinik und Poliklinik fr diagnostische und interventionelle Radiologie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; ²Klinik und Poliklinik fr Allgemein- und Abdominalchirurgie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; ³Klinik und Poliklinik fr diagnostische und interventionelle Radiologie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; ⁴Institut fr Pathologie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; ⁵Klinik und Poliklinik fr Radioonkologie sowie Strahlentherapie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; ⁶Klinik fr Allgemein-, Viszeral- und minimalinvasive Chirurgie, St. Hildegardis Krankenhaus, Mainz, Germany

To assess the therapeutic effects of neoadjuvant radio-chemotherapy on tumor microcirculation DCE- MRI parameters were measured in patients with rectum carcinoma using two slices in maximal tumor extent per patient and measurement. The results of these different models (Brix/Tofts) were compared between each other and the different slices and showed, that the slice selection did not affect later analysis and that it was not possible to find a relevant difference in therapeutic effects between the corresponding parameters of the pharmacokinetic models.