Dynamic Perfusion Study of Mouse Pancreas with an Intravascular Contrast Agent

Philip Lee¹, Xavier Golay², George K. Radda¹

Dynamic perfusion studies on mice pancreas has been carried out with an intravascular contrast agent that has long lifetime and 6-10 times higher T1-relaxivity than commonly used Gd-DTPA. This eliminates dubious positive enhancement from agents diffusion into tissue, while strengthening signal intensity. Time-to-peak is 6mins after a 30ul (1mk/kg) bolus intravenous injection. This indicator of blood flow can be used to compare the different hemodynamic responses in diabetic mice models. Coupled with fast pancreas localization scan, this study paves the way for subsequent quantification work to further understand glucose metabolism.