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Abstract #2078

Functional Liver Imaging Using Partial Least Squares (PLS) Analysis

Alyaa Hussein Elzibak1,2, Jeff Fortuna2,3, John F. MacGregor3, Colm Boylan4, Michael D. Noseworthy2,5

1Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada; 2Brain-Body Institute, St. Joseph's Healthcare, Hamilton, Ontario, Canada; 3Chemical Engineering, McMaster University, Hamilton, Ontario, Canada; 4Diagnostic Imaging, St. Joseph's Healthcare, Hamilton, Ontario, Canada; 5Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada


We developed a liver challenge procedure that relies on modulating the BOLD signal with hyperoxia and meal intake. Temporal BOLD data analysis using partial least squares (PLS) was superior to a traditional general linear model (GLM). We show how the method can differentiate healthy from diseased liver tissue.