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Abstract #2153

The Importance of T2-Correction in Quantifying Liver Fat Using 1H MR Spectroscopy

Gavin Hamilton1, Michael S. Middleton1, Takeshi Yokoo1, Joel E. Lavine2, Heather M. Patton3, Claude B. Sirlin1

1Department of Radiology, University of California, San Diego, San Diego, CA, USA; 2Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of San Diego, San Diego, CA, USA; 3Department of Medicine, University Of California, San Diego, San Diego, CA, USA

In liver 1H MR spectroscopy, spectra are often collected at a single TE, and thus the lack of T2 correction may introduce possible confounding factors. This study collects 3T MR Spectra at multiple TEs and shows correction for T2 decay is necessary for liver fat quantification to avoid systematic over-estimate of fat fraction. Collecting multiple TE spectra also minimizes errors due to T2 variability.