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Abstract #2154

Free-Breathing Imaging Techniques for Liver Iron Quantification: Comparison with a Validated Breath-Hold Technique in Patients with Iron Overload

Ralf Berthold Loeffler1, Jane Hankins2, Ray Song1, Adam M. Winchell1, Mary Beth McCarville1, Claudia Maria Hillenbrand1

1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; 2Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA

Liver iron quantification with T2* measurements is gaining clinical acceptance. So far only breath-hold techniques are validated with liver biopsies. This study compared different free-breathing techniques (regular free breathing, navigated free breathing) with a breath-hold technique that was validated with liver biopsies. Liver T2* values were very similar for the free breathing techniques and for the breath-hold technique in 3 pediatric patients with moderate to strong hepatic iron overload.