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Abstract #2157

NMR-Based Metabonomics Study on Liver and Kidney Tissues from Type 2 Diabetic Mice

Shuhui Cai1, James Y. Yang2, Jingjing Xu1, Jiyang Dong1, Zhong Chen1

1Department of Physics, Xiamen University, Xiamen, Fujian, China; 2Department of Biomedical Sciences, Xiamen University, Xiamen, Fujian, China

The whole metabolite compositions in intact liver tissues and kidney tissues from db/db mice of 8 weeks old were studied by H-1 MAS NMR spectra together with principal components analysis. The liver tissues of diabetic mice have elevated level of triglyceride and declined level of trimethylamine-N-oxide, phosphocholine, glycerophosphocholine and choline, indicating significant alteration of lipid metabolism in the diabetes biochemistry. In contrast, the biochemical changes are less obvious in kidney tissues of diabetic mice. These studies may help to explore the aetiological factor of diabetes mellitus, thus assisting with the diagnosis and prognosis in clinical practice.