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Abstract #2165

Assessment of Metabolism in the Regenerating Mouse Liver by 31P MRSI

Khushali Kotedia1, Jadegoud Yaligar1, Kaitlyn Kelly2, Joyce Wong2, Jason A. Koutcher1, Yuman Fong2, Kristen L. Zakian1

1Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA; 2Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA

Levels of 31P metabolites in the mouse liver following partial hepatectomy (70% PH) were quantitated by 31P magnetic resonance spectroscopic imaging (MRSI) to determine whether 31P metabolites were non-invasive markers of regenerative status. In each of the 2 phases of this study, the mean NTP level decreased after PH but did not differ significantly from controls. Significant changes in PME and/or PE and PC were not observed. SNR limitations due to the very small liver remnant volume as well as inter-subject heterogeneity may have resulted in statistical uncertainty that obscured the detection of metabolic changes.