Abstract #2199

T2* Mapping of Hyperpolarized 3He in the Rat Lung Using a 3D Cones Imaging Strategy

Jian-Xiong Wang¹, Jeffrey A. Stainsby², Alexei V. Ouriadov³, Matthew Fox³, Giles E. Santyr³

¹Applied Science Laboratory, GE HEALTHCARE, London, Ontario, Canada; ²Applied Science Laboratory, GE HEALTHCARE, Toronto, Ontario, Canada; ³Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada

The 3D Cones sequence utilises a central-out k-space trajectory that does not require field gradients prior to sampling. This characteristic can reduce unwanted diffusion weighting in hyperpolarized noble gas (HNG) imaging. As well, the ultra-short TE (<0.1ms) capability of the 3D Cones provides useful approach for measurement of short T2* relaxation of HNG in the lung tissues. This work presents the application of 3D Cones pulse sequence to hyperpolarized 3He gas imaging for measurement of lung volume and T2* mapping of hyperpolarized 3He gas in the rat lung.