Ran Meng1, Burkhard Meadler2, Silvia D. Chang3, Edward C. Jones4, S Larry Goldenberg5,6, Piotr Kozlowski1,6
1UBC MRI Research Centre, Vancouver, BC, Canada; 2Philips Healthcare, Vancouver, BC, Canada; 3Radiology, University of British Columbia, Vancouver, BC, Canada; 4Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; 5Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; 6The Prostate Centre at VGH, Vancouver, BC, Canada
We compared the quality of fit to the extended Kety model of the prostate DCE MRI data (acquired with 3T clinical scanner from two patients) using population-averaged and patient specific Arterial Input Function (AIF). Kinetic parameters (Ktrans, ve, and vp) were calculated from tumor, peripheral zone and central gland. By comparing Chi2 of the fit with the two AIFs of a high enhancing voxel, we conclude that patient specific AIF provides more accurate pharmacokinetic modeling of prostate DCE MRI data in high enhancing areas than population-averaged AIF, thus patient specific AIF may result in more accurate detection of prostatic carcinoma.