Abstract #2240

3T DCE MRI in Prostate Cancer Comparison Between Population Average and Patient Specific Arterial Input Function

Ran Meng¹, Burkhard Meadler², Silvia D. Chang³, Edward C. Jones⁴, S Larry Goldenberg^5,6, Piotr Kozlowski^1,6

¹UBC MRI Research Centre, Vancouver, BC, Canada; ²Philips Healthcare, Vancouver, BC, Canada; ³Radiology, University of British Columbia, Vancouver, BC, Canada; ⁴Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; ⁵Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; ⁶The Prostate Centre at VGH, Vancouver, BC, Canada

We compared the quality of fit to the extended Kety model of the prostate DCE MRI data (acquired with 3T clinical scanner from two patients) using population-averaged and patient specific Arterial Input Function (AIF). Kinetic parameters (Ktrans, ve, and vp) were calculated from tumor, peripheral zone and central gland. By comparing Chi2 of the fit with the two AIFs of a high enhancing voxel, we conclude that patient specific AIF provides more accurate pharmacokinetic modeling of prostate DCE MRI data in high enhancing areas than population-averaged AIF, thus patient specific AIF may result in more accurate detection of prostatic carcinoma.