Abstract #2243

Assessment of Registration Accuracy Between Magnetic Resonance Imaging and Three Dimensional Trans-Rectal Ultrasound Imaging of Prostate Cancer

Elmer Soto¹, Vaishali Karnik^1,2, Igor Gyacskov², Lori Gardi², Tamie L. Poepping^3,4, Gord John Campbell^4,5, Aaron Fenster^1,2, Charles Alexander McKenzie^1,4

¹Biomedical Engineering Graduate Program, The University of Western Ontario, London, Ontario, Canada; ²Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; ³Physics & Astronomy, The University of Western Ontario, London, Ontario, Canada; ⁴Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; ⁵Industrial Materials Institute - London, National Research Council Canada, London, Ontario, Canada

Trans-rectal ultrasound (TRUS) guided biopsies often underestimate or fail to detect the presence of prostate cancer (PCa). Fused MRI and 3D TRUS images have the potential to dramatically reduce the false negative rate of TRUS-guided biopsies. To validate the accu-racy of registering MR images to 3D TRUS images, a polyvinyl alcohol prostate phantom was constructed. MRI and TRUS images of the phantom were segmented and registered. The fiducial localization error and target registration error between corresponding mark-ers in the phantom was sufficiently small to suggest that our technique is accurate enough to guide prostate biopsies.