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Abstract #2253

Feasibility of Chemical Exchange Saturation Transfer (CEST) MRI for Prostate Cancer Detection at 3T

Guang Jia1, Jinyuan Zhou2, Seongjin Choi1, Wenbo Wei1, Steffen Sammet1, Jiachao Liang1, Jun Zhang1, Zarine K. Shah1, Mitva Patel1, Ronney Abaza3, Pankaj Dangle3, Douglas Martin4, Michael V. Knopp1

1Department of Radiology, The Ohio State University, Columbus, OH, USA; 2Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; 3Center for Robotic and Computer Assisted Surgery, The Ohio State University, Columbus, OH, USA; 4Department of Radiation Medicine, The Ohio State University, Columbus, OH, USA

This study is to evaluate whether CEST MRI is feasible to image prostate cancer patients for tumor detection. All subjects were imaged in a 3 Tesla MR system (Achieva, Philips) using an 8-channel SENSE Torso coil or 32-channel SENSE Torso/Cardiac coil. MT-spectrum of the prostate cancer regions revealed asymmetric water saturation profile with higher MTR at negative frequency offsets, which gave larger MTRasym (3.5ppm) in tumor regions than normal PZ and CG. This feasibility study provides a diagnostic potential of CEST MRI for tissue characterization in prostate cancer screening and lesion detection.