Abstract #2253

Feasibility of Chemical Exchange Saturation Transfer (CEST) MRI for Prostate Cancer Detection at 3T

Guang Jia¹, Jinyuan Zhou², Seongjin Choi¹, Wenbo Wei¹, Steffen Sammet¹, Jiachao Liang¹, Jun Zhang¹, Zarine K. Shah¹, Mitva Patel¹, Ronney Abaza³, Pankaj Dangle³, Douglas Martin⁴, Michael V. Knopp¹

¹Department of Radiology, The Ohio State University, Columbus, OH, USA; ²Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; ³Center for Robotic and Computer Assisted Surgery, The Ohio State University, Columbus, OH, USA; ⁴Department of Radiation Medicine, The Ohio State University, Columbus, OH, USA

This study is to evaluate whether CEST MRI is feasible to image prostate cancer patients for tumor detection. All subjects were imaged in a 3 Tesla MR system (Achieva, Philips) using an 8-channel SENSE Torso coil or 32-channel SENSE Torso/Cardiac coil. MT-spectrum of the prostate cancer regions revealed asymmetric water saturation profile with higher MTR at negative frequency offsets, which gave larger MTR_asym (3.5ppm) in tumor regions than normal PZ and CG. This feasibility study provides a diagnostic potential of CEST MRI for tissue characterization in prostate cancer screening and lesion detection.