Correlation of Endorectal 2D JPRESS Findings with Pathological Gleason Scores in Prostate Cancer Patients

Nagarajan Rajakumar¹, Daniel Margolis¹, Steven S. Raman¹, Ana Maria Gomez¹, Timothy McClure¹, Nader Binesh², Michael Albert Thomas¹

Prostate cancer is the most frequently diagnosed non-cutaneous cancer and the second leading cause of cancer deaths in American men. To determine if the metabolite ratios of choline plus creatine to citrate and choline plus creatine to spermine in patients with two ranges of pathological Gleason scores, namely (3+4) and (4+3) can be calculated using the localized two-dimensional (2D) J-resolved spectroscopy (JPRESS) and correlated with prostate cancer aggressiveness. Our pilot study suggests that 2D JPRESS can be reliably evaluated in a clinical setting using an endorectal coil, and good correlation between the metabolite ratios and the pathology based Gleason scores.