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Abstract #2257

Histologic Basis of MRI in Prostate Peripheral Zone: Determination of the Relationships Between Sub-Cellular Components and ADC, T2, Ktrans and Ve

Deanna Lyn Langer1,2, Theo H. van der Kwast3, Andrew J. Evans3, John Trachtenberg4, Brian C. Wilson5, Masoom A. Haider1,2

1Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada; 2Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; 3Department of Pathology and Laboratory Medicine, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; 4Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada; 5Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada

Histological correlates of ADC, T2, Ktrans and ve were investigated in the peripheral zone (PZ) of the prostate. Whole mount sections were digitized and segmented at histological-resolution. PZ-tissue in MRI and histology was radially-sectioned. The slope (m) of median parameter values versus %area of nuclei, cytoplasm, stroma, and lumen, was tested for significance. ADC, T2 and Ktrans were significantly related to %nuc (m<0: ADC, T2; m>0: Ktrans). Other significant relationships were between ADC and %cyt (m<0) and %lumen (m>0), although trends existed for T2 and Ktrans. This work elucidates some of the inherent relationships between MRI and underlying histology.