Haris Tsachres1, Kayvan Keshari2, Carissa Santos2, Lynn DeLosSantos3, Laura Tabatabai4, Jeffry Simko4, Katsuto Shinohara5, Peter Carroll5, Dan Vigneron3, John Kurhanewicz3
1Radiology, University of California San Francisco (UCSF), , San Francisco , CA, USA; 2Radiology, University of California San Francisco (UCSF), San Francisco , CA, USA; 3Radiology, University of California San Francisco (UCSF), San Francisco, CA, USA; 4Pathology, University of California San Francisco (UCSF), CA, USA; 5Urology, University of California San Francisco (UCSF), CA, USA
This study investigated the relationship between individual phospholipid metabolite concentrations, Gleason score, and rate of cellular proliferation in malignant prostatectomy samples by performing HR-MAS two-dimensional total correlation spectroscopy (TOCSY), pathology and Ki-67 staining on the same samples. High grade prostate cancers were found to have significantly higher concentrations of PC+GPC and higher Ki-67 staining than low grade ( 3+4) prostate cancer. Similarly, low grade prostate cancers were found to have significantly higher concentrations of PC+GPC and higher Ki-67 staining than benign samples. This is of great clinical significance since most prostate cancers are indolent and will never metastasize, but it is believed that cancers with a dominant Gleason pattern 4, even of small volume, are aggressive and potentially lethal.