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Abstract #2284

Evaluation of Functional and Structural Characteristics of Tumor Angiogenesis in Lung Cancer Overexpressing Different VEGF Isoform in a Murine Xenograft Model by Using of MR Imaging

Chia-Ming Shih1,2, Ang Yuan3, Chih-Yuan Chen2, Hao-Wei Cheng3, Chien-Yuan Lin2, Pan-Chyr Yang3, Jyh- Horng Chen1, Chen Chang2

1Department of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 3National Taiwan University Hospital, Taipei, Taiwan

Vascular endothelial growth factor (VEGF) is important for tumor associated angiogenesis. However, the different effects of VEGF isoforms (such as VEGF121, VEGF165 and VEGF189) in functional and structural characteristics of tumor angiogenesis is still unclear. The purpose of this study was to use dynamic contrast enhanced MRI and steady state contrast enhanced MRI to evaluate the in vivo vascular function using vascular transfer constant (Ktrans), and structural characteristics including microvessel density and vessel size of tumor angiogenesis induced by different VEGF isoform in non-small cell lung cancer.