Xiaobing Fan1, Chad R. Haney1, Devkumar Mustafi2, Marta Zamora1, Erica J. Markiewicz1, Gregory S. Karczmar1
1Radiology, The University of Chicago,
Chicago, IL, USA; 2Biochemistry & Molecular Biology, The
University of Chicago, Chicago, IL, USA
Accurate measurement of the arterial input function (AIF) is critical for quantitative evaluation of DCEMRI data. The reference tissue method avoids large errors associated with direct arterial measurements, but assumes that Ktrans and ve for the reference tissue are close to literature values. Here we demonstrate that this problem can be avoided by comparing a reference tissue that has low blood flow to plasma concentrations measured at one minute or greater after injection when plasma concentration can be measured accurately. These values (Ktrans/ve) are then used to calculate the entire AIF including the first pass of the contrast bolus.