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Abstract #2286

Simultaneous Determination of Blood Flow, Microvascular Permeability and Blood Volume in Lung Cancer Overexpressing Different VEGF Isoforms in a Murine Xenograft Model by Dynamic Contrast Enhancement MR Imaging (DCE-MRI)

Chia-Ming Shih1,2, Ang Yuan3, Chih-Yuan Chen2, Hao-Wei Cheng3, Ta-Wei Chou2, Pan-Chyr Yang3, Jyh- Horng Chen1, Chen Chang2

1Department of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 3National Taiwan University Hospital, Taipei, Taiwan

Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. However, biologic effects of different VEGF isoforms (such as VEGF121, VEGF165 and VEGF189) on in vivo tumor associated angiogenesis is still not clear. Adiabatic approximation to the tissue homogeneity model (AATH model) is a newly development which can be used to produce simultaneously specific angiogenic parameters, including blood flow (Fp), permeability (PSp) and blood volume (Vb). In the present study, we apply AATH model to assess angiogenesis in lung cancer overexpressing different VEGF isoforms in a murine xenograft model.