Abstract #2286

Simultaneous Determination of Blood Flow, Microvascular Permeability and Blood Volume in Lung Cancer Overexpressing Different VEGF Isoforms in a Murine Xenograft Model by Dynamic Contrast Enhancement MR Imaging (DCE-MRI)

Chia-Ming Shih^1,2, Ang Yuan³, Chih-Yuan Chen², Hao-Wei Cheng³, Ta-Wei Chou², Pan-Chyr Yang³, Jyh- Horng Chen¹, Chen Chang²

¹Department of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; ²Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; ³National Taiwan University Hospital, Taipei, Taiwan

Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. However, biologic effects of different VEGF isoforms (such as VEGF121, VEGF165 and VEGF189) on in vivo tumor associated angiogenesis is still not clear. Adiabatic approximation to the tissue homogeneity model (AATH model) is a newly development which can be used to produce simultaneously specific angiogenic parameters, including blood flow (Fp), permeability (PSp) and blood volume (Vb). In the present study, we apply AATH model to assess angiogenesis in lung cancer overexpressing different VEGF isoforms in a murine xenograft model.