Abstract #2288

Comparing Single-Shot Look Locker T1 Mapping and Dynamic 3D T1-Weighted Gradient Echo Imaging for Free Breathing Quantitative DCE-MRI in a Rat Liver Tumor Model at 1.5 T

Andreas Steingoetter¹, Jonas Svensson^1,2, Stefanie Remmele³, Rene Botnar^1,4, Markus Schwaiger¹, Ernst Rummeny⁵, Rickmer Braren⁵

¹Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitt Mnchen, Munich, Germany; ²Department of Medical Radiation Physics, Malmoe University Hospital, Lund University Malmoe, Malmoe, Sweden; ³Philips Research Europe-Hamburg, Hamburg, Germany; ⁴Division of Imaging Sciences, Kings College London School of Medicine, London, UK; ⁵Department of Radiology, Klinikum rechts der Isar, Technische Universitt Mnchen, Munich, Germany

Dynamic 3D T1-weighted gradient-echo (3DT1GRE) sequences for DCE-MRI are prone to displacement errors, motion and flow artefacts. This study compares a 2D single-shot Look-Locker T1 mapping (LLRGC) technique with a standard 3DT1GRE for non-triggered, free-breathing DCE-MRI experiments in a rat liver tumor model. For both methods, data of tumor, liver and muscle were dynamically sampled at 6s intervals after bolus-injection of a double-dose of GD-DTPA. Pharmacokinetic modelling was applied and T10, delay time Td, renal clearance rate rc, Ktrans and ve as well as goodness-of-fit were compared. 3DT1GRE underestimated Ktrans and ve for all tissues and showed lower goodness-of-fit values.