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Abstract #2295

Assessing Thermal Damage Using Dynamic Contrast Enhanced MRI

Steffen Lund Hokland1,2, Thomas Nielsen1,3, Chrit T. W. Moonen4, Hans Stdkilde-Jrgensen2, Michael R. Horsman1, Michael Pedersen2

1Department of Experimental Clincal Oncology, Aarhus University Hospital, Aarhus C, Denmark; 2The MR-Research Centre, University of Aarhus, Aarhus N, Denmark; 3Interdisciplinary Nanoscience Center (iNANO), University of Aarhus, Aarhus, Denmark; 4Imagerie Molculaire et Fontionelle de la Physiologie la Thrapie, University of Bordeaux, Bordeaux, France

Hyperthermia is a powerful enhancer of radiation in oncology even when the hyperthermia treatment does not affect tumor growth by it self. The aim of the study was to investigate whether DCE-MRI could be employed to assess hyperthermia induced tumor damage. Using our specially constructed small animal MRI-guided Focused Ultrasound system in conjunction with pre and post treatment DCE-MRI, we found that the semi-quantitative and model based parameters inferred from DCE-MRI data consistently identified hyperthermia treated tumors over non-treated, at doses that did not affect tumor growth.