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Abstract #2296

Magnetic Resonance Imaging Demonstrating Reduction of Edema by Anti-Angiogenic Treatment in a Brain Metastasis Mouse Model

Luhua Zhang1, Jeeva Munasinghe2, Juan Juan Yin1, Alan Koretsky2, Kathleen Kelly1

1National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; 2National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

Brain metastases are a common occurrence in cancer patients and its associated edema is an important cause of morbidity and mortality. Current treatments are limited with undesirable side effects. We have developed a mouse model of brain metastasis associated edema. T2 scans and DWI show the development of edema, which is confirmed by histology. After treatment with AZD2171, a VEGF receptor antagonist, T2 scans and DWI show a dramatic reduction of edema. Non-invasive imaging of this model has allowed the evaluation of the effectiveness of anti-angiogenic treatment.