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Abstract #2314

Identification of Lipids in Tissue Extracts of Astrocytic Brain Tumors

Frauke Nehen1, Wieland Willker1, Rudolf Fahlbusch2, Dieter Leibfritz1

1Institute of Organic Chemistry, University of Bremen, Bremen, Germany; 2International Neuroscience Institute Hannover, Hannover, Germany

Lipophilic tissue extracts of astrocytic brain tumors were analyzed by 1H-NMR spectroscopy. Tumor core and tumor margin differ at least by one so far unknown metabolite. It contains an olefinic subunit with one quarternary carbon identified by various 2D-NMR methods. Separation of the lipophilic extract revealed that the unknown compound belongs to the neutral lipids and appears preferentially within the triglyceride fraction.