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Abstract #2329

BOLD Signal and T2 Responses in Rat F98 and 9L Gliomas to Hypoxic Hypoxia

Neil Peter Jerome1, Khan Hekmatyar1, Risto A. Kauppinen1

1Department of Radiology, Dartmouth Medical School, Hanover, NH, USA

Two rat glioma models, F98 and 9L, were used to study effects of hypoxic hypoxia (12% inspired O2) on BOLD signal and parenchymal T2 at 7T. BOLD signal decreased by 5.3±1.7 and 10.9±4.6% in F98 and 9L gliomas, respectively and the respective T2 changes were -1.8±2.8 and -5.0±2.6ms. MR responses to carbogen (O2:CO2, 95:5) were much less reproducible in both gliomas. AMI-227 data indicated larger increase in blood volume of 9L than in F98 during hypoxia. These data indicate that hypoxic exposure may provide an indirect means of evaluating tumour vascular and metabolic adaptivity.