Jane Halliday1, Jose Ulloa1, Marietta Scott1, Graham Bigley2, Herve Barjat1, Neil Gray2, John C. Waterton1, Chris Womack2, Carsten Liess1
1Imaging, Translational Sciences, AstraZeneca, Macclesfield, Cheshire, UK; 2Cancer Histopathology, AstraZeneca, Macclesfield, Cheshire, UK
The water proton Apparent Diffusion Coefficient (ADC) has been proposed as a biomarker of the non-viable fraction in tumours. Our aim was to evaluate the correlation between ADC and histopathology in a diverse panel of human tumour xenografts commonly used in a preclinical drug efficacy evaluation. There was a significant correlation between ADC and necrosis (N=19, p=0.02) and a significant inverse correlation with proliferation (N=19, p=0.005), but no correlation with oedema.