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Abstract #2330

Apparent Diffusion Coefficient Correlates with Necrosis and Inversely with Proliferation: Histopathological Quantification in a Panel of Human Tumour Xenografts

Jane Halliday1, Jose Ulloa1, Marietta Scott1, Graham Bigley2, Herve Barjat1, Neil Gray2, John C. Waterton1, Chris Womack2, Carsten Liess1

1Imaging, Translational Sciences, AstraZeneca, Macclesfield, Cheshire, UK; 2Cancer Histopathology, AstraZeneca, Macclesfield, Cheshire, UK

The water proton Apparent Diffusion Coefficient (ADC) has been proposed as a biomarker of the non-viable fraction in tumours. Our aim was to evaluate the correlation between ADC and histopathology in a diverse panel of human tumour xenografts commonly used in a preclinical drug efficacy evaluation. There was a significant correlation between ADC and necrosis (N=19, p=0.02) and a significant inverse correlation with proliferation (N=19, p=0.005), but no correlation with oedema.