Abstract #2338

The Ex Vivo and in Vivo MR Study of Glioma Targeted Contrast Agents

Barbara Blasiak^1,2, Boguslaw Tomanek^1,3, Tadeusz Foniok³, David Kirk¹, David Rushforth³, Roger MacKenzie⁴, Abedelnasser Abulrob^4,5, Umar Iqbal⁵, Danica Stanimirovic^4,5, Xuqueng Lung¹, Peter Forsyth¹

¹Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; ²Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, malopolskie, Poland; ³Institute of Biodiagnostics(West), National Research Council of Canada, Calgary, Alberta, Canada; ⁴Institute of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada; ⁵Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada

The composition of targeted contrast agents of gliomas was investigated. The c.a. consisting of Fe3O4 and FeCo cores with SiO2 and Au shells were investigated. The relaxation times of agar solutions of the c.a. were measured ex vivo using 9.4T MRI system. To render NPs targeted high grade glioma specific single domain antibodies were conjugated with the NPs. The ex vivo results showed, that the FeCo core are more efficient than Fe3O4 core NPs. The in vivo MRI using mouse glioma model and functionalized NPs showed decrease in T2 over the tumor area, showing the efficacy of the c.a.