Abstract #2339

Synthesis and Characterization of the Tumor Targeting Contrast Agent [Gd(TTDA)] 2- Derivative for MRI

Yun-Ming Wang¹, Ying-Hsiu Lin², Chiao-Yun Chen³, Gin-Chung Liu³

¹Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; ²Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan; ³Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Bombesin (BN) is a 14 amino acid peptide that binds to gastrin-releasing peptide receptors (GRPR). GRPR has been found in a variety of cancers. In order to target GRPR, we modified TTDA derivative ligand L1 and then conjugated with BN peptide substrate. The GdL1-BN and EuL1-BN complexes were conformed by MRI and optical imaging. The results sowed that GdL1-BN had ability to target the PC-3 cell line. These results indicate that GdL1-BN is a suitable candidate for a targeted MRI contrast agent in tracing GRPR over-expression.