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Abstract #2340

Synthesis and Characterization CRGD-PEG Iron Oxide Nanoparticles of Noninvasive Imaging for Targeting α vβ 3Integrins by MRI

Yun-Ming Wang1, Jen-Yen Lin1, Yu-Ting Kao2, Gin-Chung Liu2

1Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; 2Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

The fabrication and characterization of PEG-coated magnetic nanoparticles, SPIO-mPEG-cRGD as nanoprobes for MR imaging to target specific receptors were reported. From the results, we found that the SPIO-mPEG-cRGD had well-dispersed in different pH value solutions, low protein absorption from medium, no hysteresis, high saturation magnetization and low cytotoxicity of different cells. Moreover, SPIO-mPEG-cRGD had ability to target the MCF-7, HT-29, A549, and HT-1080 cells proved by in vitro and in vivo MR imaging studies.

MRS Methodology