Saadallah Ramadan1, Eva-Maria Ratai2, Ovidiu C. Andronesi2, A Gregory Sorensen2, Carolyn E. Mountford1
1Radiology, Brigham and Women's Hospital, Boston, MA, USA; 2Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth Street, Suite 2301 , Charlestown, MA, USA
In vivo Localized Correlation Spectroscopy (L-COSY, 90ss 180ss t1 90ss Acq) is a developing technique that enables researchers to un-scramble spectroscopic findings in a relatively narrow spectral bandwidth along a second dimension, and thus, facilitating analysis and improving reliability. Chemical shift artifact, high SAR, and B1 inhomogeneity are issues that must be addressed properly to improve outcome. We here present the first application of adiabatic-Localized-COSY (AL-COSY) where spatial selection and excitation along two orientations is achieved by two pairs of slice-selective adiabatic inversion pulses, thereby increasing bandwidth and reducing B1 sensitivity.
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