Cross Peak Enhancement in Constant-Time COSY (CT-COSY)

Saadallah Ramadan¹, Carolyn E. Mountford¹

In vivo Localized Correlation Spectroscopy (L-COSY, 90ss 180ss t1 90ss Acq) is a developing technique that enables the researcher to un-scramble spectroscopic finding is a relatively narrow spectral bandwidth along a second dimension, and thus, facilitating analysis and improving reliability. However, when diagonal peaks are prominent, they can interfere with weak cross peaks. We propose here a CT-COSY method by which the amplitude of cross peaks can be improved and that of diagonal peaks reduced when the time delay between the leading 90^o and terminal 90^o increases. Theoretical reasoning is presented as well as phantom and in vivo muscle data.