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Abstract #2358

Phase-Sensitive Localized COSY (PS-LCOSY)

Saadallah Ramadan1, M Albert Thomas2

1Radiology, Brigham and Women's Hospital, Boston, MA, USA; 2Radiology and Psychiatry, David Geffen School of Medicine, Los Angeles, CA, USA

Two-dimensional (2D) localized correlation spectroscopy (L-COSY) uses three slice-selective radio-frequency pulses (900ss-1800ss-900ss) for VOI localization and coherence transfer. One of the drawbacks of L-COSY is the twisted line shapes leading to inability in resolving the cross peaks close to the diagonal of the 2D spectrum. It has been demonstrated in high resolution NMR that phase-sensitive (PS) LCOSY minimizes the twisted line shapes and enhances resolution in the direct (F2) and indirect (F1) dimensions when compared to its magnitude counterpart (4). The first application of localized phase-sensitive homonuclear correlated spectroscopy (PS-LCOSY) using a whole body MRI scanner is presented.