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Abstract #2371

Determination of Residual Dipolar Coupling in Skeletal Muscle of Upper Extremity

John Austin Vargo1, Steven L. Lindauer1, Raymond R. Raylman1, Richard G. Spencer2, M. Albert Thomas3, S. Sendhil Velan1

1Center for Advanced Imaging and Department of Radiology, West Virginia University, Morgantown, WV, USA; 2Magnetic Resonance Imaging and Spectroscopy Section, NIA, National Institutes of Health, Baltimore, MD, USA; 3Radiology, University of California Los Angeles, Los Angeles, CA, USA

The skeletal muscle spectroscopy is very complex due to the presence of scalar couplings and residual dipolar couplings. It is very important to consider the effects of residual dipolar coupling as it can change the spectral pattern and relaxation times. We have determined the residual dipolar coupling between the creatine CH3 and CH2 along with J interactions in the closed / open fist positions of flexor digitorum profundus muscle of upper extremity by advanced 1D and 2D MRS approaches.