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Abstract #2372

Identification of Urine Biomarkers for X-Ray Radiation in Mice Using NMR Spectroscopy

Congju Chen1, David J. Brenner2, Truman R. Brown1

1Department of Radiology, Columbia University, New York, USA; 2Center for Radiological Research, Columbia University, New York, USA

In the present work, we describe metabolomics for X-ray irradiation biodosimetry in a mouse model. To analyze the large number of metabolomes, we employed the high-throughput NMR technique. The results show that the X-ray exposure yields distinct urine metabolomic phenotypes in mice. Furthermore, the phenotype is dose-dependent and time-dependent. Based on the understanding acquired in this work, we will be in a position to initiate measurements of metabolomics "fingerprints" in humans who were exposed to radiation.